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Genetics Analysis and Principles 5th Edition Brooker Test Bank

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Genetics Analysis and Principles 5th Edition Brooker Test Bank

ISBN-13: 978-0073525341

ISBN-10: 0073525340

 

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Genetics Analysis and Principles 5th Edition Brooker Test Bank

ISBN-13: 978-0073525341

ISBN-10: 0073525340

 

 

 

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Chapter 11

DNA Replication

 

 

Multiple Choice Questions

  1. Which of the following best describes the double-helix of DNA?
    A.It has directionality
    B. The strands are arranged in an anti-parallel arrangement
    C. The strands are complementary
    D. All of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.01.01 Describe the structural features of DNA that enable it to be replicated.
Section: 11.01
Topic: Structural Overview Of Dna Replication

  1. The purpose of DNA replication is to produce ______.
    A.Two daughter strands
    B. Two parental strands
    C. Two template strands
    D. None of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.01.01 Describe the structural features of DNA that enable it to be replicated.
Section: 11.01
Topic: Structural Overview Of Dna Replication

 

  1. Which of the following best describes the mechanism of DNA replication in which both parental strands remain together following replication?
    A.Dispersive
    B. Semi-conservative
    C. Conservative
    D. All of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.01.02 Analyze the experiment of Meselson and Stahl and explain how the results were consistent with the semiconservative model of DNA replication.
Section: 11.01
Topic: Structural Overview Of Dna Replication

  1. Which of the following best describes the mechanism of DNA replication in which both a parental strand and daughter strand are combined following replication?
    A.Dispersive
    B. Semi-conservative
    C. Conservative
    D. All of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.01.02 Analyze the experiment of Meselson and Stahl and explain how the results were consistent with the semiconservative model of DNA replication.
Section: 11.01
Topic: Structural Overview Of Dna Replication

  1. The first generation of replication in the Meselson and Stahl experiment disproved which theory of replication?
    A.Semiconservative
    B. Conservative
    C. Dispersive
    D. None—it took more than one generation to disprove the theory

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Section: 11.01
Topic: Structural Overview Of Dna Replication

 

  1. You have isolated what appears to be alien DNA. While studying its replication, you performed the exact experiment Meselson and Stahl did. After three generations, the DNA is subjected to a CsCl gradient and only one band appears. What type of replication does this DNA undergo?
    A.Semiconservative
    B. Conservative
    C. Dispersive

 

Accessibility: Keyboard Navigation
Bloom’s Level: 5. Evaluate
Learning Outcome: 11.01.02 Analyze the experiment of Meselson and Stahl and explain how the results were consistent with the semiconservative model of DNA replication.
Section: 11.01
Topic: Structural Overview Of Dna Replication

  1. Bacterial DNA has how many origins of replication?
    A.0
    B. 1
    C. 10
    D. Depends on the size of the DNA

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.02.01 Describe the key features of a bacterial origin of replication.
Section: 11.02
Topic: Bacterial Dna Replication: The Formation Of Two Replication Forks At The Origin Of Replication

  1. Which of the following is not correct concerning the initiation of bacterial replication?
    A.It involves a region of the DNA called oriC
    B. DNA proteins bind to the DNA to begin separation of the strands
    C. The strands are initially separated at GC-rich regions of DNA
    D. Following initial separation, DNA helicase enzymes continue to unwrap the DNA

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.02.01 Describe the key features of a bacterial origin of replication.
Section: 11.02
Topic: Bacterial Dna Replication: The Formation Of Two Replication Forks At The Origin Of Replication

 

  1. DNA helicase enzymes move in what direction along the DNA during DNA replication?
    A.5′ to 3′
    B. 3′ to 5′
    C. They remain stationary

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.01 Describe how helicase, topoisomerase, and single-strand binding protein are important for the unwinding of the DNA double helix.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. Prevents supercoiling ahead of the replication fork.
    A. DNA ligase
    B.  DNA primase
    C.  Topoisomerase
    D.  DNA polymerase I
    E.  DNA polymerase III

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.01 Describe how helicase, topoisomerase, and single-strand binding protein are important for the unwinding of the DNA double helix.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. Manufactures a 10-12 base segment of RNA.
    A.DNA ligase
    B.

Primase

  1. Topoisomerase
    D.DNA polymerase I
    E. DNA polymerase III

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. Fills in small regions of DNA where the RNA primers were located.
    A.DNA ligase
    B. DNA primase
    C. Topoisomerase
    D. DNA polymerase I
    E. DNA polymerase III

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. Responsible for the majority of DNA replication.
    A.DNA ligase
    B. DNA primase
    C. Topoisomerase
    D. DNA polymerase I
    E. DNA polymerase III

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. Attaches adjacent Okazaki fragments, forming a continuous DNA strand.
    A.DNA ligase
    B. DNA primase
    C. Topoisomerase
    D. DNA polymerase I
    E. DNA polymerase III

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.03 Compare and contrast the synthesis of the leading and lagging strands.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. Synthesizes the lagging strand of the DNA.
    A.DNA ligase
    B. DNA primase
    C. Topoisomerase
    D. DNA polymerase I
    E. DNA polymerase III

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.03 Compare and contrast the synthesis of the leading and lagging strands.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. How many DNA polymerases are found in prokaryotes?
    A.5
    B. 7
    C. 9
    D. 12

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. DNA polymerases add new nucleotides in what direction?
    A.5′ to 3′
    B. 3 ‘ to 5’
    C. Both directions

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

True / False Questions
 

  1. DNA polymerase III has the ability to begin synthesis of the new daughter strands immediately following the formation of the replication fork.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 3. Apply
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

Multiple Choice Questions

  1. You have discovered a strain of E. coli that grows very slowly—the generation time is nearly 12 hours compared to the normal 20-30 minutes. Upon further investigation, you find a mutation in the DNA polymerase III gene. What subunit of the holoenzyme does this mutation affect the most?
    A.

a

b

e

d

 

 

Accessibility: Keyboard Navigation
Bloom’s Level: 5. Evaluate
Learning Outcome: 11.03.06 Explain how the isolation of mutants was instrumental in our understanding of DNA replication.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. Okazaki fragments do which of the following?
    A.Assist in forming the replication fork
    B. Bind to the oriC region
    C. Assist in the synthesis of DNA from the lagging strand
    D. Reform the double-helix following replication
    E. None of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.03 Compare and contrast the synthesis of the leading and lagging strands.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. Which of the following is an example of a processive enzyme?
    A.DNA polymerase I
    B. DNA polymerase III
    C. DNA ligase
    D. Okazaki fragments

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.04.02 Define processivity.
Section: 11.04
Topic: Bacterial Dna Replication: Chemistry And Accuracy

  1. Which of the following stops the replication of DNA in prokaryotes?
    A.Tus proteins
    B. DNA ligase
    C. Okazaki fragments
    D. The end of the chromosome

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.05 Describe how DNA replication is terminated.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. What functions are accomplished by the primosome?
    A.Tracking along DNA
    B. Tracking along DNA, separating double stranded DNA
    C. Tracking along DNA, separating double stranded DNA, synthesizing RNA primers
    D. Tracking along DNA, separating double stranded DNA, synthesizing RNA primers, adding nucleotides

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.04 List the components of the replisome.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. The proofreading of the DNA occurs in the _________.
    A.5′ to 3′ direction
    B. 3′ to 5′ direction
    C. Both directions

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.04.03 Explain the proofreading function of DNA polymerase.
Section: 11.04
Topic: Bacterial Dna Replication: Chemistry And Accuracy

  1. You extract DNA from an E. coli cell and observe it is hemi-methylated. Which strand of DNA is older?
    A.The methylated strand
    B. The strand that is not methylated
    C. Neither—they are the same “age.”

 

Accessibility: Keyboard Navigation
Bloom’s Level: 4. Analyze
Learning Outcome: 11.02.02 Explain how DnaA protein initiates DNA replication.
Section: 11.02
Topic: Bacterial Dna Replication: The Formation Of Two Replication Forks At The Origin Of Replication

 

  1. What was the control in Arthur Kornberg’s in vitro replication experiment described in this chapter?
    A. The use of radiolabeled nucleotide triphosphates
    B.  The exclusion of template DNA in one test tube
    C.  Adding perchloric acid
    D.  The use of E. coli proteins

 

Accessibility: Keyboard Navigation
Bloom’s Level: 4. Analyze
Section: 11.02
Topic: Bacterial Dna Replication: The Formation Of Two Replication Forks At The Origin Of Replication

  1. What types of mutants were essential to the discovery of new replication enzymes?
    A.Gain-of-function mutations
    B. Lethal mutations
    C. Temperature-sensitive mutations
    D. None of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 3. Apply
Learning Outcome: 11.03.06 Explain how the isolation of mutants was instrumental in our understanding of DNA replication.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. GGGCCATTCGAACGTCCGAAAATGCCCCTGAATGAAAATTTTGGCCC. The primer used for replication in vitro is CCCGGTAAGCTT. Where is the 5′ end for the template and primer, respectively?
    A.Left, left
    B. Right, left
    C. Left, right
    D. Right, right

 

Accessibility: Keyboard Navigation
Bloom’s Level: 3. Apply
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. In eukaryotes, which of the following is similar to the oriC region of prokaryotes?
    A.Dam
    B. ARS elements
    C. Promoters
    D. Telomeres

 

Accessibility: Keyboard Navigation
Bloom’s Level: 3. Apply
Learning Outcome: 11.05.01 Compare and contrast origins of replication in bacteria and eukaryotes.
Section: 11.05
Topic: Eukaryotic Dna Replication

  1. DNA polymerase is a primer-dependent enzyme that functions only in the 5′-3′ direction. These are the two most fundamental concepts to understanding this enzyme. Based on this, which of the following enzyme pairs are analogous in prokaryotes and eukaryotes?
    A.

DNA pol I : DNA pol a

DNA pol II : DNA pol b

DNA pol III : DNA pol d

  1. All of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 4. Analyze
Learning Outcome: 11.05.02 Outline the functions of different DNA polymerases in eukaryotes.
Section: 11.05
Topic: Eukaryotic Dna Replication

 

  1. DNA polymerase III is the main replication enzyme in prokaryotes. What is it in eukaryotes?
    A.DNA pol a
    B. DNA pol d
    C. DNA pol b
    D. DNA pol g

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. Lesion-replicating polymerases are _________.
    A.Only active in skin cells
    B. Used to replicate damaged DNA
    C. Used to induce genetic diversity
    D. None of the answers are correct

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.05.02 Outline the functions of different DNA polymerases in eukaryotes.
Section: 11.05
Topic: Eukaryotic Dna Replication

  1. Which of the following is NOT a reason for the high fidelity of the newly synthesized DNA molecule?
    A. The hydrogen bonding between purines and pyrimidines is stable.
    B.  The DNA polymerase is unlikely to form bonds between nucleotides if they are mismatched.
    C.  The DNA polymerase has exonuclease functions.
    D.  The DNA polymerase has the ability to change the structure of the base in order to form the correct bond.

 

Accessibility: Keyboard Navigation
Bloom’s Level: 3. Apply
Learning Outcome: 11.04.03 Explain the proofreading function of DNA polymerase.
Section: 11.04
Topic: Bacterial Dna Replication: Chemistry And Accuracy

 

  1. Which of the following is a restriction placed on DNA polymerase?
    A. DNA polymerase can attach new nucleotides only in the 5′ to 3′ direction.
    B.  DNA polymerases must begin synthesis using an RNA primer.
    C.  DNA polymerases must have a template strand to copy from.
    D.  All of these are restrictions of DNA polymerase.

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. DNA polymerases are unable to bind to what areas of the chromosome?
    A. Centromeres
    B.  3′ end of telomeres
    C.  Origins of replication

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.05.04 Explain how DNA replication occurs at the ends of eukaryotic chromosomes.
Section: 11.05
Topic: Eukaryotic Dna Replication

 

True / False Questions

  1. The Meselson-Stahl experiments used 35S radioisotopes to determine the mechanism of DNA replication.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 3. Apply
Learning Outcome: 11.01.02 Analyze the experiment of Meselson and Stahl and explain how the results were consistent with the semiconservative model of DNA replication.
Section: 11.01
Topic: Structural Overview Of Dna Replication

 

  1. The Meselson-Stahl experiments supported the model of dispersive DNA replication.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.01.02 Analyze the experiment of Meselson and Stahl and explain how the results were consistent with the semiconservative model of DNA replication.
Section: 11.01
Topic: Structural Overview Of Dna Replication

  1. The origin of replication in bacteria is called OriC.
    TRUE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.02.01 Describe the key features of a bacterial origin of replication.
Section: 11.02
Topic: Bacterial Dna Replication: The Formation Of Two Replication Forks At The Origin Of Replication

  1. Replication usually begins in GC rich regions due to the presence of only 2 hydrogen bonds between the bases.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.02.01 Describe the key features of a bacterial origin of replication.
Section: 11.02
Topic: Bacterial Dna Replication: The Formation Of Two Replication Forks At The Origin Of Replication

  1. The movement of the replication fork in bacterial replication is unidirectional.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. After the action of the helicase, single-stranded binding proteins keep the parental DNA strands from reforming a double-helix.
    TRUE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.01 Describe how helicase, topoisomerase, and single-strand binding protein are important for the unwinding of the DNA double helix.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. The synthesis of the daughter strand of DNA occurs away from the replication fork in the leading strand.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.03 Compare and contrast the synthesis of the leading and lagging strands.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. DNA polymerase III has an error in replication once every 100 million nucleotides.
    TRUE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.04.03 Explain the proofreading function of DNA polymerase.
Section: 11.04
Topic: Bacterial Dna Replication: Chemistry And Accuracy

  1. DNA polymerase III can synthesize a new strand of DNA at the rate of 300 nucleotides per minute.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.03.02 Outline how primase, DNA polymerase, and DNA ligase are needed to make strands of DNA at the replication fork.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

 

  1. Catenanes can only form in cells with circular chromosomes, such as bacteria.
    TRUE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.05 Describe how DNA replication is terminated.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. A primosome consists of a polymerase and a single-stranded binding protein.
    FALSE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 2. Understand
Learning Outcome: 11.03.04 List the components of the replisome.
Section: 11.03
Topic: Bacterial Dna Replication: Synthesis Of New Dna Strands

  1. The ability of the DNA polymerase to remove mismatched bases is called exonuclease cleavage (proofreading).
    TRUE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.04.03 Explain the proofreading function of DNA polymerase.
Section: 11.04
Topic: Bacterial Dna Replication: Chemistry And Accuracy

  1. The problem in synthesizing the 3′ end of chromosomes is solved by the use of the telomerase enzyme.
    TRUE

 

Accessibility: Keyboard Navigation
Bloom’s Level: 1. Remember
Learning Outcome: 11.05.04 Explain how DNA replication occurs at the ends of eukaryotic chromosomes.
Section: 11.05
Topic: Eukaryotic Dna Replication

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